A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis
نویسندگان
چکیده
منابع مشابه
A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis
Metastasis and chemoresistance in cancer are linked phenomena, but the molecular basis for this link is unknown. We uncovered a network of paracrine signals between carcinoma, myeloid, and endothelial cells that drives both processes in breast cancer. Cancer cells that overexpress CXCL1 and 2 by transcriptional hyperactivation or 4q21 amplification are primed for survival in metastatic sites. C...
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ژورنال
عنوان ژورنال: Cell
سال: 2012
ISSN: 0092-8674
DOI: 10.1016/j.cell.2012.04.042